Cell Type-specific Pharmacology of Nmda Receptors Using Masked Mk801 1 2
نویسندگان
چکیده
18 N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important 19 for synaptic plasticity, which is involved in learning and drug addiction. We show 20 enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined 21 neuronal population with the cell-type-selectivity of genetic methods and the 22 temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons 23 are necessary for cocaine-induced synaptic potentiation, demonstrating that cell 24 type-specific pharmacology can be used to dissect signaling pathways within 25 complex brain circuits. 26 27 28 Yang, et al.
منابع مشابه
Cell type-specific pharmacology of NMDA receptors using masked MK801
N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons are nec...
متن کاملA study of the effect of Ginkgo biloba extract on MK801 induced forgetfulness in rats
Introduction: Many people with amnesia would like to try herbal therapies. Ginkgo biloba is one of the most popular herbs which is used to treat amnesia. The beneficial effects of this plant, however, has not been scientifically assessed yet. Although, there have been some reports on the memory enhancement effect of Ginkgo biloba, the mechanism of its action is not yet explained well. Consi...
متن کاملA Possible Non-genomic Epileptogenic Properties of Estradiol Attenuated by MK801 and DNQX in Amygdala Kindled Rats
Although the epileptogenic properties of estrogens have been widely demonstrated in several models and species, the mechanism(s) by which estrogens can acutely change seizure parameters including after discharge and seizure duration remain remains to be determined. In the present study, we examined the role of NMDA (N-methyl-D-aspartate), non-NMDA and estrogenic receptors in estradiol benzoate ...
متن کاملA Possible Non-genomic Epileptogenic Properties of Estradiol Attenuated by MK801 and DNQX in Amygdala Kindled Rats
Although the epileptogenic properties of estrogens have been widely demonstrated in several models and species, the mechanism(s) by which estrogens can acutely change seizure parameters including after discharge and seizure duration remain remains to be determined. In the present study, we examined the role of NMDA (N-methyl-D-aspartate), non-NMDA and estrogenic receptors in estradiol benzoate ...
متن کاملNimodipine Protects PC12 Cells against Oxygen-Glucose Deprivation
The protective effect of a L-type calcium channel blocker, nimodipine, on cell injury induced by oxygen-glucose deprivation (OGD) in PC12 cells was investigated. PC12 cells were exposed to in-vitro oxygen-glucose deprivation (30 minutes and 60 minutes respectively) in the presence or absence of nimodipine (10mM/L) in three different time schedules (pre-24h, pre-3h and concurrently). Cellular vi...
متن کامل